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Antibiotics resistance

A breakthrough in the race to solve antibiotic resistance.

Overview

A group from the University of East Anglia and Diamond Light Source have made a breakthrough in the race to solve antibiotic resistance. Using Diamond, one of the UK’s most advanced scientific machines which produces a light 10 billion times brighter than the sun, they studied ‘super drug’ bacteria in extreme detail to identify an innovative method of disabling bacteria and preventing antibiotic resistance.

Impact

By determining the shape of this protein using Diamond’s synchrotron technology, the team has made it possible to design drugs that slot into the protein and stop it in its tracks, killing superbugs by simply disabling the camouflage. With this important defense barrier removed the bacteria cannot survive.

The discovery doesn’t come a moment too soon. The World Health Organisation has warned that antibiotic-resistance in bacteria is spreading globally, with severe consequences. Even common infections, which have been treatable for decades, can once again kill. This breakthrough is a giant leap forward in the fight against superbugs.

Key Individuals

  • Dr Neil Paterson (Diamond Light Source)
  • Group leader Prof Changjiang Dong, from UEA’s Norwich Medical School
  • Lead author PhD student Haohao Dong
  • Dr Phillip Stansfield from the University of Oxford,
  • Prof Wenjan Wang of Sun Yat-sen University

Facility Contact

Diamond Light Source
Tel.: + 44 (0) 1235 778431 
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